This study assessed the repairability among four CAD-CAM blocks repaired with different universal adhesives after aging. The CAD-CAM blocks evaluated were Polymer infiltrated ceramic network (Vita Enamic ®, VE), Zirconium-reinforced lithium silicate ceramic (Vita Suprinity®, VS), Feldspathic ceramic (Vitablocs ® Mark II, VM), and Lithium disilicate ceramic (IPS e.max® CAD, IE). Each original block was prepared into 5x5x5 mm dimensions to create 120 specimens. After being subjected to 10,000 cycles of thermocycling to simulate the oral environment conditions equivalent to one year of service, surface pretreatment was carried out by grinding and etching with a 9% hydrofluoric acid (Ultradent Porcelain Etch®). Subsequently, specimens were divided into three groups based on adhesive applied: Clearfil™ Tri-s bond Universal (CUB), Scotchbond Universal Plus® (SUP), and Monobond N® (MN, control group). Resin composite (Filtek™ Z350 XT, shade A3.5; 3M ESPE, USA) was then applied in a 2 mm thick-increment. All samples underwent another round of 10,000 cycles of thermocycling. A shear bond strength test (SBS) was performed, and the resulting data were analyzed by two-way ANOVA followed by Games-Howell or Least Significance Difference (LSD) post-hoc analysis (P < 0.05). Additionally, failure modes were examined under a stereomicroscope. Two-way ANOVA revealed significant impacts of both types of CAD-CAM blocks (P < 0.001), and universal adhesives (P < 0.001) on SBS values. Post-hoc analysis indicated that the SUP group exhibited improved repair SBS values compared with control and CUB groups (P < 0.05). VE + SUP group demonstrated the highest bond strength. The highest SBS was observed in the VE + CUB group (P < 0.05). Additionally, CAD-CAM material bonded with CUB showed significantly lower SBS compared with control groups in IE + CUB (P < 0.05). The lowest SBS was found in VM + MN (P < 0.05). In conclusion, universal adhesive containing 3-MPTES/APTES revealed superior repair bond strength across four CAD-CAM blocks. Particularly, hybrid ceramic and feldspathic ceramic exhibited favorable characteristics for repair with resin composite materials.