The current study aims to investigate the efficiency in reducing the saliva bacterial counts after rinsing a special mouthwash (chloroxylenol 0.0004%) when compared with Chlorhexidine mouthwash 0.12%. 104 dental students were divided into 4 groups for rinsing with 4 kinds of mouthwash; Chlorhexidine mouthwash 0.12%, chlorhexidine placebo, special mouthwash, and special mouthwash placebo. A 2 ml unstimulated saliva sample was collected; before and at 1, 30, 60 and 180 minutes after rinsing with each mouthwash. The saliva samples were then cultured in aerobic and anaerobic conditions and processed for differentiation and total bacterial counts. Chlorhexidine 0.12% mouthwash was found to be more efficient than special mouthwash in reducing saliva bacterial counts at every sample time point. The efficiency in reducing saliva bacterial count of special going dental procedures can reduce anaerobic bacteria, and it can last for up to 3 hours. This experiment shows that special mouthwash cannot replace Chlorhexidine mouthwash 0.12% in rinsing before undergoing dental procedures.The current study aims to investigate the efficiency in reducing the saliva bacterial counts after rinsing a special mouthwash (chloroxylenol 0.0004%) when compared with Chlorhexidine mouthwash 0.12%. 104 dental students were divided into 4 groups for rinsing with 4 kinds of mouthwash; Chlorhexidine mouthwash 0.12%, chlorhexidine placebo, special mouthwash, and special mouthwash placebo. A 2 ml unstimulated saliva sample was collected; before and at 1, 30, 60 and 180 minutes after rinsing with each mouthwash. The saliva samples were then cultured in aerobic and anaerobic conditions and processed for differentiation and total bacterial counts. Chlorhexidine 0.12% mouthwash was found to be more efficient than special mouthwash in reducing saliva bacterial counts at every sample time point. The efficiency in reducing saliva bacterial count of special going dental procedures can reduce anaerobic bacteria, and it can last for up to 3 hours. This experiment shows that special mouthwash cannot replace Chlorhexidine mouthwash 0.12% in rinsing before undergoing dental procedures.